Ontology highlight
ABSTRACT:
SUBMITTER: Qiu J
PROVIDER: S-EPMC4991667 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Qiu Juhui J Fan Xiaoying X Wang Yixia Y Jin Hongbin H Song Yixiao Y Han Yang Y Huang Shenghong S Meng Yaping Y Tang Fuchou F Meng Anming A
Journal of molecular cell biology 20160601 4
Hematopoietic stem cells (HSCs) replenish all types of blood cells. It is debating whether HSCs in adults solely originate from the aorta-gonad-mesonephros (AGM) region, more specifically, the dorsal aorta, during embryogenesis. Here, we report that somite hematopoiesis, a previously unwitnessed hematopoiesis, can generate definitive HSCs (dHSCs) in zebrafish. By transgenic lineage tracing, we found that a subset of cells within the forming somites emigrate ventromedially and mix with lateral pl ...[more]