Ontology highlight
ABSTRACT:
SUBMITTER: Dai S
PROVIDER: S-EPMC2287197 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Immunity 20080228 3
To test whether highly crossreactive alphabeta T cell receptors (TCRs) produced during limited negative selection best illustrate evolutionarily conserved interactions between TCR and major histocompatibility complex (MHC) molecules, we solved the structures of three TCRs bound to the same MHC II peptide (IAb-3K). The TCRs had similar affinities for IAb-3K but varied from noncrossreactive to extremely crossreactive with other peptides and MHCs. Crossreactivity correlated with a shrinking, increa ...[more]