Ontology highlight
ABSTRACT:
SUBMITTER: Maurice F
PROVIDER: S-EPMC2288771 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
EMBO reports 20080222 4
The emergence of multi-resistant pathogenic bacteria is a worldwide health issue. Recently, clinical variants of a single antibiotic-modifying acetyltransferase, AAC(6')-Ib-a variant of aminoglycoside 6'-N-acetyltransferase-have been identified that confer extended resistance to most aminoglycosides and, more surprisingly, to structurally unrelated fluoroquinolones. The corresponding gene is carried by mobile genetic elements and is present in most multi-resistant pathogenic strains, hence makin ...[more]