Ontology highlight
ABSTRACT:
SUBMITTER: Sarmiento C
PROVIDER: S-EPMC2290849 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Sarmiento Corina C Wang Weigang W Dovas Athanassios A Yamaguchi Hideki H Sidani Mazen M El-Sibai Mirvat M Desmarais Vera V Holman Holly A HA Kitchen Susan S Backer Jonathan M JM Alberts Art A Condeelis John J
The Journal of cell biology 20080301 6
We examined the role of the actin nucleation promoters neural Wiskott-Aldrich syndrome protein (N-WASP) and WAVE2 in cell protrusion in response to epidermal growth factor (EGF), a key regulator in carcinoma cell invasion. We found that WAVE2 knockdown (KD) suppresses lamellipod formation and increases filopod formation, whereas N-WASP KD has no effect. However, simultaneous KD of both proteins results in the formation of large jagged protrusions with lamellar properties and increased filopod fo ...[more]