EQED: an efficient method for interpreting eQTL associations using protein networks.
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ABSTRACT:
SUBMITTER: Suthram S
PROVIDER: S-EPMC2290938 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Publications
eQED: an efficient method for interpreting eQTL associations using protein networks.
Suthram Silpa S Beyer Andreas A Karp Richard M RM Eldar Yonina Y Ideker Trey T
Molecular systems biology 20080304
Analysis of expression quantitative trait loci (eQTLs) is an emerging technique in which individuals are genotyped across a panel of genetic markers and, simultaneously, phenotyped using DNA microarrays. Because of the spacing of markers and linkage disequilibrium, each marker may be near many genes making it difficult to finely map which of these genes are the causal factors responsible for the observed changes in the downstream expression. To address this challenge, we present an efficient met ...[more]
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