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ABSTRACT:
SUBMITTER: Regnstrom K
PROVIDER: S-EPMC22927 | biostudies-literature | 1999 Oct
REPOSITORIES: biostudies-literature
Regnström K K Sauge-Merle S S Chen K K Burgess B K BK
Proceedings of the National Academy of Sciences of the United States of America 19991001 22
In Azotobacter vinelandii, deletion of the fdxA gene that encodes a well characterized seven-iron ferredoxin (FdI) is known to lead to overexpression of the FdI redox partner, NADPH:ferredoxin reductase (FPR). Previous studies have established that this is an oxidative stress response in which the fpr gene is transcriptionally activated to the same extent in response to either addition of the superoxide propagator paraquat to the cells or to fdxA deletion. In both cases, the activation occurs th ...[more]