Enhanced Ca2+ leak from ER Ca2+ stores induced by hepatitis C NS5A protein.
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ABSTRACT:
SUBMITTER: Robinson LC
PROVIDER: S-EPMC2292798 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Publications
Enhanced Ca2+ leak from ER Ca2+ stores induced by hepatitis C NS5A protein.
Robinson Lisbeth C LC Marchant Jonathan S JS
Biochemical and biophysical research communications 20080205 3
The hepatitis C non-structural protein 5A (NS5A) is a Zn(2+)-binding phosphoprotein essential for viral replication. Expression of NS5A perturbs intracellular Ca(2+) levels by an undefined mechanism, activating transcription factors implicated in the chronic pathogenesis of hepatitis infections. Here, we demonstrate that regulated expression of NS5A enhanced the passive leak of Ca(2+) from a subset of the endoplasmic reticulum (ER) Ca(2+) stores. This action was not replicated by expression of t ...[more]
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