Evolution of the hepcidin gene in primates.
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ABSTRACT:
SUBMITTER: Segat L
PROVIDER: S-EPMC2294130 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Publications
Evolution of the hepcidin gene in primates.
Segat Ludovica L Pontillo Alessandra A Milanese Michele M Tossi Alessandro A Crovella Sergio S
BMC genomics 20080305
<h4>Background</h4>Hepcidin/LEAP-1 is an iron regulatory hormone originally identified as an antimicrobial peptide. As part of a systematic analysis of the evolution of host defense peptides in primates, we have sequenced the orthologous gene from 14 species of non-human primates.<h4>Results</h4>The sequence of the mature peptide is highly conserved amongst all the analyzed species, being identical to the human one in great apes and gibbons, with a single residue conservative variation in Old-Wo ...[more]
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