Ontology highlight
ABSTRACT:
SUBMITTER: Herbert A
PROVIDER: S-EPMC22942 | biostudies-literature | 1997 Aug
REPOSITORIES: biostudies-literature
Herbert A A Alfken J J Kim Y G YG Mian I S IS Nishikura K K Rich A A
Proceedings of the National Academy of Sciences of the United States of America 19970801 16
Editing of RNA changes the read-out of information from DNA by altering the nucleotide sequence of a transcript. One type of RNA editing found in all metazoans uses double-stranded RNA (dsRNA) as a substrate and results in the deamination of adenosine to give inosine, which is translated as guanosine. Editing thus allows variant proteins to be produced from a single pre-mRNA. A mechanism by which dsRNA substrates form is through pairing of intronic and exonic sequences before the removal of nonc ...[more]