Ontology highlight
ABSTRACT:
SUBMITTER: Gertz M
PROVIDER: S-EPMC2311372 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Gertz Melanie M Fischer Frank F Wolters Dirk D Steegborn Clemens C
Proceedings of the National Academy of Sciences of the United States of America 20080414 15
Cell fate and organismal lifespan are controlled by a complex signaling network whose dysfunction can cause a variety of aging-related diseases. An important protection against these failures is cellular apoptosis, which can be induced by p66(Shc) in response to cellular stress. The precise mechanisms of p66(Shc) action and regulation and the function of the p66(Shc)-specific N terminus remain to be identified. Here, we show that the p66(Shc) N terminus forms a redox module responsible for apopt ...[more]