Ontology highlight
ABSTRACT:
SUBMITTER: Matute C
PROVIDER: S-EPMC23152 | biostudies-literature | 1997 Aug
REPOSITORIES: biostudies-literature
Matute C C Sánchez-Gómez M V MV Martínez-Millán L L Miledi R R
Proceedings of the National Academy of Sciences of the United States of America 19970801 16
In cultured oligodendrocytes isolated from perinatal rat optic nerves, we have analyzed the expression of ionotropic glutamate receptor subunits as well as the effect of the activation of these receptors on oligodendrocyte viability. Reverse transcription-PCR, in combination with immunocytochemistry, demonstrated that most oligodendrocytes differentiated in vitro express the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunits GluR3 and GluR4 and the kainate receptor ...[more]