BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.
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ABSTRACT:
SUBMITTER: Yazdankhah M
PROVIDER: S-EPMC8526037 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.
Yazdankhah Meysam M Ghosh Sayan S Shang Peng P Stepicheva Nadezda N Hose Stacey S Liu Haitao H Chamling Xitiz X Tian Shenghe S Sullivan Mara L G MLG Calderon Michael Joseph MJ Fitting Christopher S CS Weiss Joseph J Jayagopal Ashwath A Handa James T JT Sahel José-Alain JA Zigler J Samuel JS Kinchington Paul R PR Zack Donald J DJ Sinha Debasish D
Autophagy 20210119 10
Retinal ganglion cell axons are heavily myelinated (98%) and myelin damage in the optic nerve (ON) severely affects vision. Understanding the molecular mechanism of oligodendrocyte progenitor cell (OPC) differentiation into mature oligodendrocytes will be essential for developing new therapeutic approaches for ON demyelinating diseases. To this end, we developed a new method for isolation and culture of ON-derived oligodendrocyte lineage cells and used it to study OPC differentiation. A critical ...[more]
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