Ontology highlight
ABSTRACT:
SUBMITTER: Kamatari YO
PROVIDER: S-EPMC2323848 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20030401 4
It has been established in a number of studies that the alkaline-denatured state of pepsin (the I(P) state) is composed of a compact C-terminal lobe and a largely unstructured N-terminal lobe. In the present study, we have investigated the residual structure in the I(P) state in more detail, using limited proteolysis to isolate and characterize a tightly folded core region from this partially denatured pepsin. The isolated core region corresponds to the 141 C-terminal residues of the pepsin mole ...[more]