Ontology highlight
ABSTRACT:
SUBMITTER: Moosa MM
PROVIDER: S-EPMC6588398 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Moosa Mahdi Muhammad MM Goodman Asha Z AZ Ferreon Josephine C JC Lee Chul Won CW Ferreon Allan Chris M ACM Deniz Ashok A AA
European biophysics journal : EBJ 20171027 1
Protein thermodynamic stability is intricately linked to cellular function, and altered stability can lead to dysfunction and disease. The linear extrapolation model (LEM) is commonly used to obtain protein unfolding free energies ([Formula: see text]) by extrapolation of solvent denaturation data to zero denaturant concentration. However, for some proteins, different denaturants result in non-coincident LEM-derived [Formula: see text] values, raising questions about the inherent assumption that ...[more]