Ontology highlight
ABSTRACT:
SUBMITTER: Lutz B
PROVIDER: S-EPMC2326103 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Lutz Barry B Dentinger Claire C Sun Lei L Nguyen Lienchi L Zhang Jingwu J Chmura Aj A Allen April A Chan Selena S Knudsen Beatrice B
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20071210 4
Surface-enhanced Raman scattering (SERS) nanoparticles are emerging as a new approach for optical detection of biomolecules. In a model assay in formalin-fixed paraffin-embedded (FFPE) prostate tissue sections, we detect prostate-specific antigen (PSA) using antibody (Ab) conjugated to composite organic-inorganic nanoparticles (COINs), and we use identical staining protocols to compare COIN-Ab and Alexa-Ab conjugates in adjacent tissue sections. Spectral analysis illustrates the fundamental diff ...[more]