Ontology highlight
ABSTRACT:
SUBMITTER: Kim D
PROVIDER: S-EPMC3200545 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Kim Dongwoo D Daniel Weston L WL Mirkin Chad A CA
Analytical chemistry 20091101 21
We report the use of electroless gold deposition as a light scattering signal enhancer in a multiplexed, microarray-based scanometric immunoassay using gold nanoparticle probes. The use of gold development results in greater signal enhancement than the typical silver development, and multiple rounds of metal development were found to increase the resulting signal compared to one development. Using these conditions, the assay was capable of detecting 300 aM (approximately 9000 copies) of prostate ...[more]