Ontology highlight
ABSTRACT:
SUBMITTER: Kim C
PROVIDER: S-EPMC2329691 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Kim Chun C Wilcox-Adelman Sarah S Sano Yasuyo Y Tang Wei-Jen WJ Collier R John RJ Park Jin Mo JM
Proceedings of the National Academy of Sciences of the United States of America 20080421 16
Bacillus anthracis, the etiologic agent of anthrax, avoids immune surveillance and commandeers host macrophages as a vehicle for lymphatic spreading. Here, we show that B. anthracis edema toxin (ET), via its adenylyl cyclase activity, dramatically increases the motility of infected macrophages and the expression of vascular endothelial growth factor. The transcription factor CREB and the syndecan-1 gene, a CREB target, play crucial roles in ET-induced macrophage migration. These molecular and ce ...[more]