Ontology highlight
ABSTRACT:
SUBMITTER: Reynolds G
PROVIDER: S-EPMC7611557 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Reynolds Gary G Vegh Peter P Fletcher James J Poyner Elizabeth F M EFM Stephenson Emily E Goh Issac I Botting Rachel A RA Huang Ni N Olabi Bayanne B Dubois Anna A Dixon David D Green Kile K Maunder Daniel D Engelbert Justin J Efremova Mirjana M Polański Krzysztof K Jardine Laura L Jones Claire C Ness Thomas T Horsfall Dave D McGrath Jim J Carey Christopher C Popescu Dorin-Mirel DM Webb Simone S Wang Xiao-Nong XN Sayer Ben B Park Jong-Eun JE Negri Victor A VA Belokhvostova Daria D Lynch Magnus D MD McDonald David D Filby Andrew A Hagai Tzachi T Meyer Kerstin B KB Husain Akhtar A Coxhead Jonathan J Vento-Tormo Roser R Behjati Sam S Lisgo Steven S Villani Alexandra-Chloé AC Bacardit Jaume J Jones Philip H PH O'Toole Edel A EA Ogg Graham S GS Rajan Neil N Reynolds Nick J NJ Teichmann Sarah A SA Watt Fiona M FM Haniffa Muzlifah M
Science (New York, N.Y.) 20210101 6527
The skin confers biophysical and immunological protection through a complex cellular network established early in embryonic development. We profiled the transcriptomes of more than 500,000 single cells from developing human fetal skin, healthy adult skin, and adult skin with atopic dermatitis and psoriasis. We leveraged these datasets to compare cell states across development, homeostasis, and disease. Our analysis revealed an enrichment of innate immune cells in skin during the first trimester ...[more]