Structure of the catalytic domain of the hyperthermophilic chitinase from Pyrococcus furiosus.
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ABSTRACT:
SUBMITTER: Nakamura T
PROVIDER: S-EPMC2330115 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
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Structure of the catalytic domain of the hyperthermophilic chitinase from Pyrococcus furiosus.
Nakamura Tsutomu T Mine Shouhei S Hagihara Yoshihisa Y Ishikawa Kazuhiko K Uegaki Koichi K
Acta crystallographica. Section F, Structural biology and crystallization communications 20061216 Pt 1
The crystal structure of the catalytic domain of a chitinase from the hyperthermophilic archaeon Pyrococcus furiosus (AD2(PF-ChiA)) has been determined at 1.5 A resolution. This is the first structure of the catalytic domain of an archaeal chitinase. The overall structure of AD2(PF-ChiA) is a TIM-barrel fold with a tunnel-like active site that is a common feature of family 18 chitinases. Although the catalytic residues (Asp522, Asp524 and Glu526) are conserved, comparison of the conserved residu ...[more]
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