Ontology highlight
ABSTRACT:
SUBMITTER: Santiago C
PROVIDER: S-EPMC2330274 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Santiago César C Ballesteros Angela A Martínez-Muñoz Laura L Mellado Mario M Kaplan Gerardo G GG Freeman Gordon J GJ Casasnovas José M JM
Immunity 20071201 6
The T cell immunoglobulin and mucin domain (TIM) proteins are important regulators of T cell responses. Crystal structures of the murine TIM-4 identified a metal-ion-dependent ligand binding site (MILIBS) in the immunoglobulin (Ig) domain of the TIM family. The characteristic CC' loop of the TIM domain and the hydrophobic FG loop shaped a narrow cavity where acidic compounds penetrate and coordinate to a metal ion bound to conserved residues in the TIM proteins. The structure of phosphatidylseri ...[more]