Ontology highlight
ABSTRACT:
SUBMITTER: Yuan X
PROVIDER: S-EPMC2350232 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Yuan Xu X Yao Jun J Norris David D Tran David D DD Bram Richard J RJ Chen Gong G Luscher Bernhard B
Molecular and cellular neurosciences 20080313 2
Accumulation of GABA(A) receptors (GABA(A)Rs) at GABAergic synapses requires the cytoplasmic loop region and C-terminal transmembrane domain of the receptor gamma2 subunit. We here report a novel interaction of gamma2 with Calcium-Modulating cyclophilin Ligand (CAML), an integral membrane protein that regulates this mechanism. Interaction of GABA(A)Rs with CAML depends on both the cytoplasmic region and fourth transmembrane domain of the gamma2 subunit, CAML immunoprecipitates with GABA(A)Rs fro ...[more]