Ontology highlight
ABSTRACT:
SUBMITTER: Jacob TC
PROVIDER: S-EPMC2718332 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Jacob Tija C TC Wan Qin Q Vithlani Mansi M Saliba Richard S RS Succol Francesca F Pangalos Menelas N MN Moss Stephen J SJ
Proceedings of the National Academy of Sciences of the United States of America 20090714 30
GABA(A) receptors (GABA(A)Rs), the principal sites of synaptic inhibition in the brain, are dynamic entities on the neuronal cell surface, but the role their membrane trafficking plays in shaping neuronal activity remains obscure. Here, we examined this by using mutant receptor beta3 subunits (beta3S408/9A), which have reduced binding to the clathrin adaptor protein-2, a critical regulator of GABA(A)R endocytosis. Neurons expressing beta3S408/9A subunits exhibited increases in the number and siz ...[more]