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Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study.


ABSTRACT: Energy-adjusted magnesium intake was nonsignificantly inversely related to risk of colorectal cancer (n=2328) in the Netherlands Cohort Study on Diet and Cancer that started in 1986 (n=58 279 men and 62 573 women). Statistically significant inverse trends in risk were observed in overweight subjects for colon and proximal colon cancer across increasing quintiles of magnesium uptake (P-trend, 0.05 and 0.02, respectively). Although an overall protective effect was not afforded, our results suggest an effect of magnesium in overweight subjects, possibly through decreasing insulin resistance.

SUBMITTER: van den Brandt PA 

PROVIDER: S-EPMC2360034 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature

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Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study.

van den Brandt P A PA   Smits K M KM   Goldbohm R A RA   Weijenberg M P MP  

British journal of cancer 20070201 3


Energy-adjusted magnesium intake was nonsignificantly inversely related to risk of colorectal cancer (n=2328) in the Netherlands Cohort Study on Diet and Cancer that started in 1986 (n=58 279 men and 62 573 women). Statistically significant inverse trends in risk were observed in overweight subjects for colon and proximal colon cancer across increasing quintiles of magnesium uptake (P-trend, 0.05 and 0.02, respectively). Although an overall protective effect was not afforded, our results suggest  ...[more]

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