Ontology highlight
ABSTRACT:
SUBMITTER: Hlubek F
PROVIDER: S-EPMC2361298 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Hlubek F F Pfeiffer S S Budczies J J Spaderna S S Jung A A Kirchner T T Brabletz T T
British journal of cancer 20060601 11
Overexpression of the transcriptional activator beta-catenin, mostly owing to loss-of-function mutations of the adenomatous polyposis coli (APC) tumour suppressor gene, is crucial for the initiation and progression of human colorectal carcinogenesis. Securin is a regulator of chromosome separation and its overexpression has been shown to be involved in different tumour-promoting processes, like transformation, hyperproliferation and angiogenesis, and correlates with tumour cell invasion. However ...[more]