Ontology highlight
ABSTRACT:
SUBMITTER: Mori MX
PROVIDER: S-EPMC2363160 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Mori Masayuki X MX Vander Kooi Craig W CW Leahy Daniel J DJ Yue David T DT
Structure (London, England : 1993) 20080401 4
Calmodulin (CaM) regulation of Ca(2+) channels is central to Ca(2+) signaling. Ca(V)1 versus Ca(V)2 classes of these channels exhibit divergent forms of regulation, potentially relating to customized CaM/IQ interactions among different channels. Here we report the crystal structures for the Ca(2+)/CaM IQ domains of both Ca(V)2.1 and Ca(V)2.3 channels. These highly similar structures emphasize that major CaM contacts with the IQ domain extend well upstream of traditional consensus residues. Surpr ...[more]