Ontology highlight
ABSTRACT:
SUBMITTER: Palmieri G
PROVIDER: S-EPMC2363459 | biostudies-literature | 2000 Dec
REPOSITORIES: biostudies-literature
Palmieri G G Cossu A A Ascierto P A PA Botti G G Strazzullo M M Lissia A A Colombino M M Casula M M Floris C C Tanda F F Pirastu M M Castello G G
British journal of cancer 20001201 12
Malignant melanoma (MM) is thought to arise by sequential accumulation of genetic alterations in normal melanocytes. Previous cytogenetic and molecular studies indicated the 9p21 as the chromosomal region involved in MM pathogenesis. In addition to the CDKN genes (p16/CDKN2A, p15/CDKN2B and p19(ARF), frequently inactivated in familial MM), widely reported data suggested the presence within this region of other melanoma susceptibility gene(s). To clearly assess the role of the 9p21 region in spor ...[more]