Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC2364701 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
The Journal of cell biology 20080501 3
Centrosome duplication is tightly controlled in coordination with DNA replication. The molecular mechanism of centrosome duplication remains unclear. Previous studies found that a fraction of human proline-directed phosphatase Cdc14B associates with centrosomes. However, Cdc14B's involvement in centrosome cycle control has never been explored. Here, we show that depletion of Cdc14B by RNA interference leads to centriole amplification in both HeLa and normal human fibroblast BJ and MRC-5 cells. I ...[more]