Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC2366162 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Yang Lili L Yang Haiguang H Rideout Kendra K Cho Taehoon T Joo Kye Il KI Ziegler Leslie L Elliot Abigail A Walls Anthony A Yu Dongzi D Baltimore David D Wang Pin P
Nature biotechnology 20080224 3
We report a method of inducing antigen production in dendritic cells by in vivo targeting with lentiviral vectors that specifically bind to the dendritic cell-surface protein DC-SIGN. To target dendritic cells, we enveloped the lentivector with a viral glycoprotein from Sindbis virus engineered to be DC-SIGN-specific. In vitro, this lentivector specifically transduced dendritic cells and induced dendritic cell maturation. A high frequency (up to 12%) of ovalbumin (OVA)-specific CD8(+) T cells an ...[more]