Ontology highlight
ABSTRACT:
SUBMITTER: Graveley BR
PROVIDER: S-EPMC2366815 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Cell 20051001 1
Drosophila Dscam encodes 38,016 distinct axon guidance receptors through the mutually exclusive alternative splicing of 95 variable exons. Importantly, known mechanisms that ensure the mutually exclusive splicing of pairs of exons cannot explain this phenomenon in Dscam. I have identified two classes of conserved elements in the Dscam exon 6 cluster, which contains 48 alternative exons--the docking site, located in the intron downstream of constitutive exon 5, and the selector sequences, which a ...[more]