Ontology highlight
ABSTRACT:
SUBMITTER: Mandinova A
PROVIDER: S-EPMC2367396 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Mandinova Anna A Lefort Karine K Tommasi di Vignano Alice A Stonely Wesley W Ostano Paola P Chiorino Giovanna G Iwaki Haruhi H Nakanishi Jotaro J Dotto G Paolo GP
The EMBO journal 20080403 8
Notch signalling has an important role in skin homeostasis, promoting keratinocyte differentiation and suppressing tumorigenesis. Here we show that this pathway also has an essential anti-apoptotic function in the keratinocyte UVB response. Notch1 expression and activity are significantly induced, in a p53-dependent manner, by UVB exposure of primary keratinocytes as well as intact epidermis of both mouse and human origin. The apoptotic response to UVB is increased by deletion of the Notch1 gene ...[more]