Ontology highlight
ABSTRACT:
SUBMITTER: Peng X
PROVIDER: S-EPMC2373317 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Peng Xu X Wu Xiaoyang X Druso Joseph E JE Wei Huijun H Park Ann Yong-Jin AY Kraus Marc S MS Alcaraz Ana A Chen Ju J Chien Shu S Cerione Richard A RA Guan Jun-Lin JL
Proceedings of the National Academy of Sciences of the United States of America 20080430 18
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that plays an important role in integrin-mediated signal transduction. To explore the role and mechanisms of FAK in cardiac development, we inactivated FAK in embryonic cardiomyocytes by crossing the floxed FAK mice with myosin light chain-2a (MLC2a) Cre mice, which expressed Cre as early as embryonic day 9.5 in the heart. The majority of conditional FAK knockout mice generated from MLC2a-Cre (CFKO-2a) died in the embryonic stage with ...[more]