Ontology highlight
ABSTRACT:
SUBMITTER: Beierle EA
PROVIDER: S-EPMC3171213 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Frontiers in bioscience (Elite edition) 20110101 2
Neuroblastoma is the most common extracranial solid tumor of childhood. This tumor is characterized by poor survival, especially when it features amplification of the MYCN oncogene. The ability for human cancers to propagate is marked by their ability to invade and metastasize to distant sites. Focal adhesion kinase (FAK) is a key tyrosine kinase involved in the survival and metastasis of a number of human tumor types. We have shown that FAK is present in human neuroblastoma and that its express ...[more]