Ontology highlight
ABSTRACT:
SUBMITTER: Liu VW
PROVIDER: S-EPMC2376924 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Liu V W S VW Yang H J HJ Wang Y Y Tsang P C K PC Cheung A N Y AN Chiu P M PM Ng T Y TY Wong L C LC Nagley P P Ngan H Y S HY
British journal of cancer 20030801 4
To investigate the occurrence of somatic mitochondrial DNA (mtDNA) mutations in human primary endometrial carcinomas, we sequenced the D-loop region, the 12S and 16S rRNA genes of mtDNA of cancer tissues and their matched normal controls. About 56% (28 out of 50) of cases carry one or more somatic changes in mtDNA including deletion, point mutation and mitochondrial microsatellite instability (mtMSI), namely the change in length of short base-repetitive sequences of mtDNA. In particular, mtMSI w ...[more]