Ontology highlight
ABSTRACT:
SUBMITTER: Silva S
PROVIDER: S-EPMC6205488 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Silva Sonia S Camino Lola P LP Aguilera Andrés A
Proceedings of the National Academy of Sciences of the United States of America 20181009 43
R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological as they are important drivers of genome instability and have been associated with human diseases. The mitochondrial degradosome is a functionally conserved complex from bacteria to human mitochondria. It is composed of the ATP-dependent RNA and ...[more]