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Synthesis and bio-imaging application of highly luminescent mercaptosuccinic acid-coated CdTe nanocrystals.

ABSTRACT: Here we present a facile one-pot method to prepare high-quality CdTe nanocrystals in aqueous phase. In contrast to the use of oxygen-sensitive NaHTe or H(2)Te as Te source in the current synthetic methods, we employ more stable sodium tellurite as the Te source for preparing highly luminescent CdTe nanocrystals in aqueous solution. By selecting mercaptosuccinic acid (MSA) as capping agent and providing the borate-citrate acid buffering solution, CdTe nanocrystals with high quantum yield (QY >70% at pH range 5.0-8.0) can be conveniently prepared by this method. The influence of parameters such as the pH value of the precursor solution and the molar ratio of Cd(2+) to Na(2)TeO(3) on the QY of CdTe nanocrystals was systematically investigated in our experiments. Under optimal conditions, the QY of CdTe nanocrystals is even high up to 83%. The biological application of luminescent MSA-CdTe to HEK 293 cell imaging was also illustrated.

SUBMITTER: Ying E

PROVIDER: S-EPMC2377334 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature

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Synthesis and bio-imaging application of highly luminescent mercaptosuccinic acid-coated CdTe nanocrystals.

Ying Erbo E Li Dan D Guo Shaojun S Dong Shaojun S Wang Jin J

PloS one 20080521 5

Here we present a facile one-pot method to prepare high-quality CdTe nanocrystals in aqueous phase. In contrast to the use of oxygen-sensitive NaHTe or H(2)Te as Te source in the current synthetic methods, we employ more stable sodium tellurite as the Te source for preparing highly luminescent CdTe nanocrystals in aqueous solution. By selecting mercaptosuccinic acid (MSA) as capping agent and providing the borate-citrate acid buffering solution, CdTe nanocrystals with high quantum yield (QY >70% ...[more]

PMID: 18493618

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Project description:Recently, CsPbX3 (X= Cl, Br, I) nanocrystals (NCs) have evolved as a potential contender for various optoelectronic applications due to some of their excellent photophysical properties. Their superior non-linear optical properties enable them to take part in bioimaging applications due to their longer penetration depth and less scattering effect in living cells. However, the poor stability of perovskite NCs in aqueous media still remains a great challenge for practical usage. Comparatively stable silica-coated NCs have a tendency to agglomerate among other NCs and transform into bigger particles. Such big particles clog the inside of narrow channels during the uptake and can't effectively reach the targeted cells. To tackle such issues, we introduce a fast and reproducible synthesis process of CsPbBr3 NCs that are coated with different long-chained organic ligands/polymers and compared their photophysical properties. Among them, polyvinylpyrrolidone (PVP) encapsulated NCs are highly luminescent in the green spectral region and showed a maximum photoluminescence quantum yield (PLQY) of up to 84%. The incorporation of n-isopropyl acrylamide (NIPAM) along with PVP further improves the stability of the PVP-coated NCs against heat and moisture. These NCs exhibit higher water stability compared to silica-coated NCs and maintained their emission properties for about one week in DI water. The smaller particle size, uniform size distribution, higher structural stability, and better dispersivity of polymer-coated NCs in the aqueous media enable them to perform as fluorescent probes for live cell imaging in mammalian Chinese Hamster Ovary (CHO-K1) cells. There is no adverse affect in the cells' viability and morphology even after long incubation periods (∼72 hours). The dosage of Pb-ions contained in the polymer-coated NCs is calculated as below 5 μg mL−1, which is suitable for live cell imaging. This work provides insight for expanding the use of these NCs significantly into bioimaging applications with higher sensitivity. PVP and NIPAM-coated CsPbBr3 NCs are highly luminescent and show excellent stability. These monodispersed NCs were successfully tested as a fluorescent probe for live cell imaging resulting in less cytotoxicity and high sensitivity.

Dataset Information

Synthesis and bio-imaging application of highly luminescent mercaptosuccinic acid-coated CdTe nanocrystals.

Publications

Synthesis and bio-imaging application of highly luminescent mercaptosuccinic acid-coated CdTe nanocrystals.

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