Ontology highlight
ABSTRACT:
SUBMITTER: Zhang HM
PROVIDER: S-EPMC2377423 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Zhang Hong-Mei HM Li Li L Papadopoulou Nektaria N Hodgson Glenn G Evans Emma E Galbraith Matthew M Dear Mark M Vougier Stéphanie S Saxton Janice J Shaw Peter E PE
Nucleic acids research 20080311 8
Many eukaryotic genes are acutely regulated by extra-cellular signals. The c-fos serum response element (SRE) mediates transcriptional activation in response to mitogens through serum response factor (SRF)-dependent recruitment of Elk-1, a mitogen-activated protein kinase (MAPK)-responsive transcription factor. How subsequent events at SRE promoters stimulate initiation of transcription has yet to be fully resolved. Here we show that extra-cellular signal-regulated kinase (ERK) and mitogen and s ...[more]