Ontology highlight
ABSTRACT:
SUBMITTER: Blackwood CA
PROVIDER: S-EPMC7843984 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Blackwood Christopher A CA McCoy Michael T MT Ladenheim Bruce B Cadet Jean Lud JL
Scientific reports 20210128 1
To identify signaling pathways activated by oxycodone self-administration (SA), Sprague-Dawley rats self-administered oxycodone for 20 days using short-(ShA, 3 h) and long-access (LgA, 9 h) paradigms. Animals were euthanized 2 h after SA cessation and dorsal striata were used in post-mortem molecular analyses. LgA rats escalated their oxycodone intake and separated into lower (LgA-L) or higher (LgA-H) oxycodone takers. LgA-H rats showed increased striatal protein phosphorylation of ERK1/2 and MS ...[more]