Ontology highlight
ABSTRACT:
SUBMITTER: Kijima M
PROVIDER: S-EPMC2383942 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Kijima Mika M Yamaguchi Takeshi T Ishifune Chieko C Maekawa Yoichi Y Koyanagi Akemi A Yagita Hideo H Chiba Shigeru S Kishihara Kenji K Shimada Mitsuo M Yasutomo Koji K
Proceedings of the National Academy of Sciences of the United States of America 20080505 19
Natural killer (NK) cells regulate various immune responses by exerting cytotoxic activity or secreting cytokines. The interaction of NK cells with dendritic cells (DC) contributes to NK cell-mediated antitumor or antimicrobial responses. However, the cellular and molecular mechanisms for controlling this interaction are largely unknown. Here, we show an involvement of Jagged2-Notch interaction in augmenting NK cell cytotoxicity mediated by DC. Enforced expression of Jagged2 on A20 cells (Jag2-A ...[more]