Ontology highlight
ABSTRACT:
SUBMITTER: Tong Z
PROVIDER: S-EPMC2383970 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Tong Zongzhong Z Yang Zhenglin Z Patel Shrena S Chen Haoyu H Gibbs Daniel D Yang Xian X Hau Vincent S VS Kaminoh Yuuki Y Harmon Jennifer J Pearson Erik E Buehler Jeanette J Chen Yuhong Y Yu Baifeng B Tinkham Nicholas H NH Zabriskie Norman A NA Zeng Jiexi J Luo Ling L Sun Jennifer K JK Prakash Manvi M Hamam Rola N RN Tonna Stephen S Constantine Ryan R Ronquillo Cecinio C CC Sadda SriniVas S Avery Robert L RL Brand John M JM London Nyall N Anduze Alfred L AL King George L GL Bernstein Paul S PS Watkins Scott S Jorde Lynn B LB Li Dean Y DY Aiello Lloyd Paul LP Pollak Martin R MR Zhang Kang K
Proceedings of the National Academy of Sciences of the United States of America 20080505 19
Significant morbidity and mortality among patients with diabetes mellitus result largely from a greatly increased incidence of microvascular complications. Proliferative diabetic retinopathy (PDR) and end stage renal disease (ESRD) are two of the most common and severe microvascular complications of diabetes. A high concordance exists in the development of PDR and ESRD in diabetic patients, as well as strong familial aggregation of these complications, suggesting a common underlying genetic mech ...[more]