Ontology highlight
ABSTRACT:
SUBMITTER: Xing S
PROVIDER: S-EPMC2384138 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Xing Shu S Wanting Tina Ho TH Zhao Wanming W Ma Junfeng J Wang Shaofeng S Xu Xuesong X Li Qingshan Q Fu Xueqi X Xu Mingjiang M Zhao Zhizhuang Joe ZJ
Blood 20080311 10
The JAK2(V617F) mutation was found in most patients with myeloproliferative disorders (MPDs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. We have generated transgenic mice expressing the mutated enzyme in the hematopoietic system driven by a vav gene promoter. The mice are viable and fertile. One line of the transgenic mice, which expressed a lower level of JAK2(V617F), showed moderate elevations of blood cell counts, whereas another line with a higher leve ...[more]