Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice.
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ABSTRACT:
SUBMITTER: Fraszczak J
PROVIDER: S-EPMC6326955 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice.
Fraszczak Jennifer J Vadnais Charles C Rashkovan Marissa M Ross Julie J Beauchemin Hugues H Chen Riyan R Grapton Damien D Khandanpour Cyrus C Möröy Tarik T
Leukemia 20180620 1
Growth factor independent 1 (Gfi1) controls myeloid differentiation by regulating gene expression and limits the activation of p53 by facilitating its de-methylation at Lysine 372. In human myeloid leukemia, low GFI1 levels correlate with an inferior prognosis. Here, we show that knockdown (KD) of Gfi1 in mice causes a fatal myeloproliferative disease (MPN) that could progress to leukemia after additional mutations. Both KO and KD mice accumulate myeloid cells that show signs of metabolic stress ...[more]
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