Ontology highlight
ABSTRACT:
SUBMITTER: Zhang B
PROVIDER: S-EPMC2386719 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Zhang Binzhi B Ramesh Ganesan G Uematsu Satoshi S Akira Shizuo S Reeves W Brian WB
Journal of the American Society of Nephrology : JASN 20080206 5
The molecular mechanisms of acute kidney injury (AKI) remain unclear. Toll-like receptors (TLRs), widely expressed on leukocytes and kidney epithelial cells, regulate innate and adaptive immune responses. The present study examined the role of TLR signaling in cisplatin-induced AKI. Cisplatin-treated wild-type mice had significantly more renal dysfunction, histologic damage, and leukocytes infiltrating the kidney than similarly treated mice with a targeted deletion of TLR4 [Tlr4(-/-)]. Levels of ...[more]