Ontology highlight
ABSTRACT:
SUBMITTER: Tauseef M
PROVIDER: S-EPMC3478927 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Tauseef Mohammad M Knezevic Nebojsa N Chava Koteswara R KR Smith Monica M Sukriti Sukriti S Gianaris Nicholas N Obukhov Alexander G AG Vogel Stephen M SM Schraufnagel Dean E DE Dietrich Alexander A Birnbaumer Lutz L Malik Asrar B AB Mehta Dolly D
The Journal of experimental medicine 20121008 11
Lung vascular endothelial barrier disruption and the accompanying inflammation are primary pathogenic features of acute lung injury (ALI); however, the basis for the development of both remains unclear. Studies have shown that activation of transient receptor potential canonical (TRPC) channels induces Ca(2+) entry, which is essential for increased endothelial permeability. Here, we addressed the role of Toll-like receptor 4 (TLR4) intersection with TRPC6-dependent Ca(2+) signaling in endothelia ...[more]