Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC2386735 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Liu Jiangxin J Zhang Jiahai J Yang Yinshan Y Huang Hongda H Shen Weiqun W Hu Qi Q Wang Xingsheng X Wu Jihui J Shi Yunyu Y
Protein science : a publication of the Protein Society 20080414 6
Leukemia-associated Rho guanine nucleotide exchange factor (LARG) is a RhoA-specific guanine nucleotide exchange factor (GEF) that can activate RhoA. The PDZ (PSD-95/Disc-large/ZO-1 homology) domain of LARG interacts with membrane receptors, which can relay extracellular signals to RhoA signal transduction pathways. Until now there is no structural and dynamic information about these interactions. Here we report the NMR structures of the LARG PDZ in the apo form and in complex with the plexin-B1 ...[more]