Ontology highlight
ABSTRACT:
SUBMITTER: Chang YJ
PROVIDER: S-EPMC4709268 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Chang Ying-Ju YJ Pownall Scott S Jensen Thomas E TE Mouaaz Samar S Foltz Warren W Zhou Lily L Liadis Nicole N Woo Minna M Hao Zhenyue Z Dutt Previn P Bilan Philip J PJ Klip Amira A Mak Tak T Stambolic Vuk V
eLife 20151029
Adipose tissue is crucial for the maintenance of energy and metabolic homeostasis and its deregulation can lead to obesity and type II diabetes (T2D). Using gene disruption in the mouse, we discovered a function for a RhoA-specific guanine nucleotide exchange factor PDZ-RhoGEF (Arhgef11) in white adipose tissue biology. While PDZ-RhoGEF was dispensable for a number of RhoA signaling-mediated processes in mouse embryonic fibroblasts, including stress fiber formation and cell migration, it's delet ...[more]