Ontology highlight
ABSTRACT:
SUBMITTER: Barger JL
PROVIDER: S-EPMC2386967 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Barger Jamie L JL Kayo Tsuyoshi T Vann James M JM Arias Edward B EB Wang Jelai J Hacker Timothy A TA Wang Ying Y Raederstorff Daniel D Morrow Jason D JD Leeuwenburgh Christiaan C Allison David B DB Saupe Kurt W KW Cartee Gregory D GD Weindruch Richard R Prolla Tomas A TA
PloS one 20080604 6
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg(-1) day(-1)), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interven ...[more]