Effect of caloric restriction and rapamycin on ovarian aging in mice.

ABSTRACT: Caloric restriction (CR) increases the preservation of the ovarian primordial follicular reserve, which can potentially delay menopause. Rapamycin also increases preservation on the ovarian reserve, with similar mechanism to CR. Therefore, the aim of our study was to evaluate the effects of rapamycin and CR on metabolism, ovarian reserve, and gene expression in mice. Thirty-six female mice were allocated into three groups: control, rapamycin-treated (4 mg/kg body weight every other day), and 30% CR. Caloric restricted females had lower body weight (P??0.05) and induced insulin resistance (P?

SUBMITTER: Garcia DN 

PROVIDER: S-EPMC6815295 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature