Ontology highlight
ABSTRACT:
SUBMITTER: Garcia J
PROVIDER: S-EPMC2387229 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Garcia Jacqueline J Shea John J Alvarez-Vasquez Fernando F Qureshi Asfia A Luberto Chiara C Voit Eberhard O EO Del Poeta Maurizio M
Molecular systems biology 20080415
Cryptococcus neoformans (Cn) is the most common cause of fungal meningitis worldwide. In infected patients, growth of the fungus can occur within the phagolysosome of phagocytic cells, especially in non-activated macrophages of immunocompromised subjects. Since this environment is characteristically acidic, Cn must adapt to low pH to survive and efficiently cause disease. In the present work, we designed, tested, and experimentally validated a theoretical model of the sphingolipid biochemical pa ...[more]