The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans.
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ABSTRACT:
SUBMITTER: Munshi MA
PROVIDER: S-EPMC5839121 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans.
Munshi Mansa A MA Gardin Justin M JM Singh Ashutosh A Luberto Chiara C Rieger Robert R Bouklas Tejas T Fries Bettina C BC Del Poeta Maurizio M
Cell reports 20180201 6
Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans possesses a remarkable ability to disseminate through an immunocompromised host, making treatment difficult. Here, we examine the mechanism of survival of C. neoformans under varying host conditions and find a role for ceramide synthase in C. neoformans virulence. This study also provides a detailed lipidomics resource fo ...[more]
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