Ontology highlight
ABSTRACT:
SUBMITTER: Ueda H
PROVIDER: S-EPMC2390961 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Ueda Hiroyuki H Miyazaki Yoichi Y Matsusaka Taiji T Utsunomiya Yasunori Y Kawamura Tetsuya T Hosoya Tatsuo T Ichikawa Iekuni I
Journal of the American Society of Nephrology : JASN 20080213 4
Bone morphogenetic protein (BMP) 4 exerts multiple biological effects on kidney and ureter development. To examine the role of BMP4 in glomerular morphogenesis, we generated transgenic mice with altered BMP4 function in podocytes by conferring tissue-specificity with the nephrin (Nphs1) promoter. At birth, Tg(Nphs1-Nog) mice, which had loss of BMP4 function in podocytes, were found to have glomerular microaneurysms, collapsed glomerular capillary tufts, enlarged Bowman's capsules, and fewer norm ...[more]